综述：视神经脊髓炎的白细胞抗原免疫遗传学
Humanleukocyteantigens-immunogeicsofneuromyelitisopticaorDevicsdiseaseandtheimpactontheimmunopathogenesis,diagnosisandtreatment:acriticalreview
1DepartmentofNeurology,MedicalSchoolofNationalandKapodistrianUniversityofAthens,AeginitionHospital,Athens,Greece2DepartmentofNeurology;DepartmentofNeurology,ImmunogeicsLaboratoryandDivisionofDemyelinatingDiseases,MedicalSchoolofNationalandKapodistrianUniversityofAthens,AeginitionHospital,Athens,Greece
CorrespondenceAddress:MariaPanosGontikaDepartmentofNeurology,ImmunogeicsLaboratoryandDivisionofDemyelinatingDiseases,MedicalSchoolofNationalandKapodistrianUniversityofAthens,AeginitionHospital,VassilisisSofiasAvenue,AthensGreece
Abstract
Neuromyelitisoptica(NMO)isanautoimmunedemyelinatingdisorder,predominantlycharacterizedbysevereopticneuritis,transversemyelitisandthehighlevelofantibodiesagainstaquaporin-4(AQP4)orNMO-immunoglobulinG(IgG).ResearchestryingtocorrelateNMOwithspecifichumanleukocyteantigen(HLA)vertheless,ithasbe
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